8-Methylquinoline-5-carboxylic acid → 8-Methyl-1,2,3,4-tetrahydroquinoline-5-carboxylic acid

HRID 1385044노트

반응식

HRID 1385044 반응식
[CH3:1][C:2]1[C:11]2[N:10]=[CH:9][CH:8]=[CH:7][C:6]=2[C:5]([C:12]([OH:14])=[O:13])=[CH:4][CH:3]=1.[H][H]>C(O)C.[Pd]>[CH3:1][C:2]1[C:11]2[NH:10][CH2:9][CH2:8][CH2:7][C:6]=2[C:5]([C:12]([OH:14])=[O:13])=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 129507838-Methylquinoline-5-carboxylic acidHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 139517338-Methyl-1,2,3,4-tetrahydroquinoline-5-carboxylic acid

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

0.1 mol of 8-methylquinoline-5-carboxylic acid was suspended in 1.5 l of ethanol and admixed with 10.0 g of palladium on activated carbon (5%). Over a period of 48 hours, the mixture was reduced in an autoclave at 50° C. using hydrogen (1 bar) (HPLC control). The reaction mixture was then filtered, the filter cake was washed with ethanol and the combined organic filtrates were concentrated.

후처리

  1. customwas reduced in an autoclave at 50° C.
  2. filtrationThe reaction mixture was then filtered
  3. washthe filter cake was washed with ethanol
  4. concentrationthe combined organic filtrates were concentrated

출처 및 근거

ORD 기록
ord-d95a369dc23b41f4a78cbb3cc939dca0
출처 데이터셋
uspto-grants-2001_07
특허 번호
US06262074B1

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