Water → N-(4-aminophenyl)-2-hydroxybenzamide

HRID 1385158노트

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HRID 1385158 반응식
C([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11](=[O:20])[NH:12][C:13]1[CH:18]=[CH:17][C:16]([NH2:19])=[CH:15][CH:14]=1)(=O)C.C(=O)(O)[O-].[Na+].O.[Cl-].[Na+]>CO>[NH2:19][C:16]1[CH:15]=[CH:14][C:13]([NH:12][C:11](=[O:20])[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[OH:4])=[CH:18][CH:17]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 5234Sodium ChlorideHCID 516892Sodium BicarbonateHCID 18543278HCID 18543278, 화합물

생성물 1

HCID 2781453N-(4-aminophenyl)-2-hydroxybenzamide

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
80 °C

실험 절차

To a solution of 2-(4-aminophenylcarbamoyl)phenyl acetate (580 mg) in methanol (10 mL) is added saturated sodium bicarbonate (2 mL) and water (3 mL). The mixture is heated at 80° C. for 30 minutes, then poured into half-saturated aqueous sodium chloride and extracted with ethyl acetate. The ethyl acetate solution is dried over anhydrous sodium sulfate and concentrated under reduced pressure to give an oil which is then triturated with diethyl ether to provide the desired product as a white solid.

후처리

  1. extractionextracted with ethyl acetate
  2. dry with materialThe ethyl acetate solution is dried over anhydrous sodium sulfate
  3. concentrationconcentrated under reduced pressure
  4. customto give an oil which
  5. customis then triturated with diethyl ether

출처 및 근거

ORD 기록
ord-f114876feee048db8c9a97646038b614
출처 데이터셋
uspto-grants-2001_07
특허 번호
US06262082B1

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