3-Methoxyphenyl isocyanate → N-(2-hydroxy-4-nitrophenyl)-N'-(3-methoxyphenyl)urea

HRID 1385345노트

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HRID 1385345 반응식
[OH:1][C:2]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:3]=1[NH2:4].[CH3:12][O:13][C:14]1[CH:15]=[C:16]([N:20]=[C:21]=[O:22])[CH:17]=[CH:18][CH:19]=1>>[OH:1][C:2]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:3]=1[NH:4][C:21]([NH:20][C:16]1[CH:17]=[CH:18][CH:19]=[C:14]([O:13][CH3:12])[CH:15]=1)=[O:22]

참가 물질

3

반응물 2

HCID 878433-Methoxyphenyl isocyanateHCID 49847212-Amino-5-Nitrophenol

생성물 1

HCID 21184674N-(2-hydroxy-4-nitrophenyl)-N'-(3-methoxyphenyl)urea수율 46.2%

실험 절차

N-(2-Hydroxy-4-nitrophenyl)-N′-(3-methoxyphenyl)urea was prepared from 2-hydroxy 4-nitro aniline (154 mg, 1.0 mmol) and 3-methoxy phenyl isocyanate (1.0 mmol) according to the procedure in General Method B. The product was purified by dilution with methylene chloride and precipitation with hexanes. Filtering afforded the title compound (140 mg, 46%). EI-MS m/z 302 (M−H)−

후처리

  1. customThe product was purified by dilution with methylene chloride and precipitation with hexanes
  2. filtrationFiltering

출처 및 근거

ORD 기록
ord-e64663e71b0c4d20bfd4b941fff362be
출처 데이터셋
uspto-grants-2001_07
특허 번호
US06262113B1

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