Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzene, 1-isocyanato-2-methoxy- → CXCR2 antagonist 8
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzene, 1-isocyanato-2-methoxy- | HCID 69695 | — |
| 반응물 | 2-Amino-5-Nitrophenol | HCID 4984721 | — |
| 생성물 | CXCR2 antagonist 8 | HCID 9796445 | 27% |
반응 단계
N-(2-Hydroxy-4-nitrophenyl)-N′-(2-methoxyphenyl)urea was prepared from 2-hydroxy 4-nitro aniline (154 mg, 1.0 mmol) and 2-methoxy phenyl isocyanate (1 mmol.) according to the procedure in General Method B. The product was purified by dilution with methylene chloride and precipitation with hexanes. Filtering afforded the title compound (82 mg, 27%). EI-MS m/z 302 (M−H)−
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06262113B1 |
| 출처 데이터셋 | uspto-grants-2001_07 |
| ORD ID | ord-2ddabcb6303c49b89aff50ab6d7d7887 |
| 출처 메모 | uspto-grants-2001_07 |