1-Isocyanato-2-(methylsulfanyl)benzene → N-(2-hydroxy-4-nitro phenyl) N'-(2-methylthio phenyl) urea

HRID 1385359

반응식

HRID 1385359 반응식
[OH:1][C:2]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:3]=1[NH2:4].[CH3:12][S:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[N:20]=[C:21]=[O:22]>>[OH:1][C:2]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:3]=1[NH:4][C:21]([NH:20][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=1[S:13][CH3:12])=[O:22]

참가 물질

3

반응물 2

HCID 27369891-Isocyanato-2-(methylsulfanyl)benzeneHCID 49847212-Amino-5-Nitrophenol

생성물 1

HCID 9840030N-(2-hydroxy-4-nitro phenyl) N'-(2-methylthio phenyl) urea수율 61%

실험 절차

The urea was prepared from 2-hydroxy 4-nitro aniline (500 mg, 3.24 mmol) and 2-methylthio phenyl isocyanate (3.24 mmol) by general Method B. The product was purified by dilution with methylene chloride and precipitation with hexanes. Filtering afforded the title compound (0.63 g, 61%). EI-MS m/z 320 (M+H)+

후처리

  1. customThe product was purified by dilution with methylene chloride and precipitation with hexanes
  2. filtrationFiltering

출처 및 근거

ORD 기록
ord-e311a3ab8214479a9a1f38d72c00f309
출처 데이터셋
uspto-grants-2001_07
특허 번호
US06262113B1

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