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Imidazole → (2r)-1-(4-Bromophenoxy)-4-(3-pyridyl)-2-(tert-butyldimethylsilyloxy)butane

HRID 1386018
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HRID 1386018 반응식
[Si:1](Cl)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].N1C=CN=C1.[Br:14][C:15]1[CH:32]=[CH:31][C:18]([O:19][CH2:20][C@H:21]([OH:30])[CH2:22][CH2:23][C:24]2[CH:25]=[N:26][CH:27]=[CH:28][CH:29]=2)=[CH:17][CH:16]=1>ClCCl>[Br:14][C:15]1[CH:16]=[CH:17][C:18]([O:19][CH2:20][C@H:21]([O:30][Si:1]([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2])[CH2:22][CH2:23][C:24]2[CH:25]=[N:26][CH:27]=[CH:28][CH:29]=2)=[CH:31][CH:32]=1
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참가 물질

5

반응물 3

HCID 795ImidazoleHCID 28928tert-Butyldimethylsilyl chlorideHCID 53756856(2R)-1-(4-bromophenoxy)-4-(3-pyridyl)-2-butanol

생성물 1

HCID 54062431(2r)-1-(4-Bromophenoxy)-4-(3-pyridyl)-2-(tert-butyldimethylsilyloxy)butane수율 99.7%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

tert-Butyldimethylsilylchloride (3.75 g) and imidazole (1.69 g) were added to a solution of (2R)-1-(4-bromophenoxy)-4-(3-pyridyl)-2-butanol (4 g, Example 21a)) in dichloromethane. The mixture was stirred for 16 hours at room temperature. The white precipitate was collected by filtration and the filtrate concentrated under reduced pressure to give the sub-title compound as an oil (5.4 g)

후처리

  1. filtrationThe white precipitate was collected by filtration
  2. concentrationthe filtrate concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-70552c409e884970afd47d504e5b74a3
출처 데이터셋
uspto-grants-2001_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06265409B1

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