Sodium Cyanide → tert-butyl (2R)-2-(cyanomethyl)pyrrolidine-1-carboxylate
반응식
CS(O[C@:6]1([CH3:18])[CH2:10][CH2:9][CH2:8][N:7]1[C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])(=O)=O.[C-:19]#[N:20].[Na+]>CN(C=O)C>[C:19]([CH2:18][C@H:6]1[CH2:10][CH2:9][CH2:8][N:7]1[C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])#[N:20]참가 물질
4
반응 조건
- 온도
- 60 °C
실험 절차
To a solution of (R)-2-methanesulfonyloxy-methyl-pyrrolidine-1-carboxylic acid, tert-butyl ester (D3) (90 g, 0.32 mol) in DMF (1200 ml) was added sodium cyanide (24 g, 0.49 mol). Heated to 60° C. overnight. Reaction mixture was concentrated and partitioned between water and ether. The organic phase was dried and concentrated to give the title compound (18 g, 30%) (M-Boc) 110.
후처리
- customReaction mixture
- concentrationwas concentrated
- custompartitioned between water and ether
- customThe organic phase was dried
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-e9d3ce2b88874421a88b078b734a74b2
- 출처 데이터셋
- uspto-grants-2001_07
- 특허 번호
- US06265408B1
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