Potassium Iodide → HCID 21717342, 화합물

HRID 1386076노트

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HRID 1386076 반응식
[NH2:1][C:2]1[C:3]2[N:4]([C:9]([CH3:13])=[C:10]([CH3:12])[N:11]=2)[CH:5]=[C:6]([CH3:8])[CH:7]=1.[CH2:14]([C:16]1[CH:23]=[C:22]([F:24])[CH:21]=[C:20]([CH3:25])[C:17]=1[CH2:18]Br)[CH3:15].[I-].[K+].C([O-])([O-])=O.[Na+].[Na+]>C(COC)OC>[CH2:14]([C:16]1[CH:23]=[C:22]([F:24])[CH:21]=[C:20]([CH3:25])[C:17]=1[CH2:18][NH:1][C:2]1[C:3]2[N:4]([C:9]([CH3:13])=[C:10]([CH3:12])[N:11]=2)[CH:5]=[C:6]([CH3:8])[CH:7]=1)[CH3:15]

참가 물질

6

반응물 4

HCID 4875Potassium IodideHCID 10340Sodium CarbonateHCID 21717327HCID 21717327, 화합물HCID 226726328-Amino-2,3,6-trimethylimidazo[1,2-a]pyridine

생성물 1

HCID 21717342HCID 21717342, 화합물수율 29%

시약·촉매·용매 1

HCID 80711,2-Dimethoxyethane용매

실험 절차

8-Amino-2,3,6-trimethylimidazo[1,2-a]pyridine (0.38 g, 2.16 mmol) and 2-ethyl-4-fluoro-6-methylbenzylbromide (0.50 g, 2.16 mmol) were dissolved in 10 ml dimethoxyethane. Potassium iodide (0.2 g, 1.2 mmol) and Na2CO3 (0.4 g, 3.8 mmol) were added and the mixture was refluxed for 6 hours. The solvent was evaporated and the residue was purified by column chromatography on silica gel using a mixture of methylene chloride and ethyl acetate (60:40) as eluent. 203 mg (29%) of the title compound was obtained.

후처리

  1. temperaturethe mixture was refluxed for 6 hours
  2. customThe solvent was evaporated
  3. customthe residue was purified by column chromatography on silica gel using
  4. additiona mixture of methylene chloride and ethyl acetate (60:40) as eluent

출처 및 근거

ORD 기록
ord-14bc3e2bfc4f43fc9ca11e04c3ae6f34
출처 데이터셋
uspto-grants-2001_07
특허 번호
US06265415B1

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