Acetic Acid → 4-[4-(4-Octyloxyphenyl)piperazin-1-yl]benzoic acid

HRID 1386589노트

반응식

HRID 1386589 반응식
[CH2:1]([O:9][C:10]1[CH:15]=[CH:14][C:13]([N:16]2[CH2:21][CH2:20][N:19]([C:22]3[CH:29]=[CH:28]C(C#N)=[CH:24][CH:23]=3)[CH2:18][CH2:17]2)=[CH:12][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].O.[C:31]([OH:34])(=[O:33])[CH3:32]>OS(O)(=O)=O>[CH2:1]([O:9][C:10]1[CH:15]=[CH:14][C:13]([N:16]2[CH2:21][CH2:20][N:19]([C:22]3[CH:29]=[CH:28][C:32]([C:31]([OH:34])=[O:33])=[CH:24][CH:23]=3)[CH2:18][CH2:17]2)=[CH:12][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 962WaterHCID 211822454-[4-(4-Octyloxyphenyl)piperazin-1-yl]benzonitrile

생성물 1

HCID 211824374-[4-(4-Octyloxyphenyl)piperazin-1-yl]benzoic acid

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

실험 절차

A solution of 4-[4-(4-Octyloxyphenyl)piperazin-1-yl]benzonitrile (0.5 g) in 20% H2SO4 aqueous solution (30 ml) and acetic acid (20 ml) was refluxed for 9 hours. The reaction mixture was pulverized with water. The precipitate was collected by filtration, and added to a mixture of water, tetrahydrofuran and ethyl acetate, and adjusted to pH 2.5 with 1N NaOH aqueous solution. The organic layer was taken, and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure to give 4-[4-(4-Octyloxyphenyl)piperazin-1-yl]benzoic acid (388 mg).

후처리

  1. filtrationThe precipitate was collected by filtration
  2. additionadded to a mixture of water, tetrahydrofuran and ethyl acetate
  3. dry with materialdried over magnesium sulfate
  4. filtrationThe magnesium sulfate was filtered off
  5. customthe filtrate was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-9fdcf6f81db1442c8545cabde755941a
출처 데이터셋
uspto-grants-2001_07
특허 번호
US06265536B1

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