Trifluoroacetic acid → HCID 69929667, 화합물

HRID 1386639노트

반응식

HRID 1386639 반응식
C(O[C:6](=O)[N:7]([C@H:9]([C:25](=[O:38])[NH:26][CH2:27][C:28]1([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH2:31][CH2:30][CH2:29]1)[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:13][CH:12]=1)C)(C)(C)C.[C:40]([OH:46])([C:42]([F:45])([F:44])[F:43])=[O:41]>C(Cl)Cl>[F:43][C:42]([F:45])([F:44])[C:40]([OH:46])=[O:41].[CH2:18]([O:17][C:14]1[CH:15]=[CH:16][C:11]([CH2:10][C@H:9]([NH:7][CH3:6])[C:25]([NH:26][CH2:27][C:28]2([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[CH2:29][CH2:30][CH2:31]2)=[O:38])=[CH:12][CH:13]=1)[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 69927875HCID 69927875, 화합물

생성물 1

HCID 69929667HCID 69929667, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of (S)-{2-(4-Benzyloxy-phenyl)-1-[(1-phenyl-cyclobutylmethyl)-carbamoyl]-ethyl}-methyl-carbamic acid tert-butyl ester (from Step 1; 1.07 g, 2.02 mmol) in methylene chloride (10 mL) was added TFA (2.5 mL). The solution was stirred at room temperature for 2 hours and then concentrated in vacuo. Coevaporisation with methylene chloride was carried out twice to give the desired product which was used without further purification.

후처리

  1. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-a77e9a68e2c84c0bb6c3fce371c3bc61
출처 데이터셋
uspto-grants-2001_07
특허 번호
US06265382B1

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