Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 2-(R)-(3-(S)-((4-(3-(4-Fluorophenyl)propyl)-4-hydroxy-piperidin-1-yl)methyl)-4-(S)-phenylpyrrolidin-1-yl)-2-(cyclohexyl)acetic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 4-[3-(4-Fluorophenyl)propyl]piperidin-4-ol | HCID 18364876 | — |
| 반응물 | 2-(R)-(3-(R)-formyl-4-(S)-phenylpyrrolidin-1-yl)-2-(cyclohexyl)acetic acid, benzyl ester | HCID 59924617 | — |
| 생성물 | 2-(R)-(3-(S)-((4-(3-(4-Fluorophenyl)propyl)-4-hydroxy-piperidin-1-yl)methyl)-4-(S)-phenylpyrrolidin-1-yl)-2-(cyclohexyl)acetic acid | HCID 20672373 | — |
반응 단계
The title compound was prepared from 2-(R)-(3-(R)-Formyl-4-(S)-phenylpyrrolidin-1-yl)-2-(cyclohexyl)acetic acid, benzyl ester (from EXAMPLE 1, Step I) and 4-hydroxy-4-(3-(4-fluorophenyl)propyl) piperidine.HCl (from EXAMPLE 110, Step A) using procedures analogous to those described in EXAMPLE 1, Steps J and K. For the title compound: ESI-MS 537 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06265434B1 |
| 출처 데이터셋 | uspto-grants-2001_07 |
| ORD ID | ord-7b91175471fc491080b14c28e972e1a3 |
| 출처 메모 | uspto-grants-2001_07 |