돌아가기
Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1386829생성일: 2026년 10월 26일

Potassium Carbonate → 5-Methylisoxazole-4-carboxylic acid (4-(3-iodopropoxy)phenyl)amide

https://huagongshe.com/reaction/1386829

반응식

참여 물질

역할이름HCID투입량
반응물Potassium CarbonateHCID 11430—
반응물1,3-DiiodopropaneHCID 12314—
반응물N-(4-Hydroxyphenyl)-5-methyl-1,2-oxazole-4-carboxamideHCID 19439747—
생성물5-Methylisoxazole-4-carboxylic acid (4-(3-iodopropoxy)phenyl)amideHCID 53804942—

반응 단계

6.5 g (0.03 mol) of 5-methylisoxazole-4-carboxylic acid (4-hydroxyphenyl)amide are dissolved in 57 ml (0.5 mol) of 1,3-diiodopropane and 26.2 g (0.19 mol) of finely ground potassium carbonate are added with intensive stirring. The reaction is complete after approximately 4 h. Working up is carried out by means of filtration, concentration and chromatography on silica gel by means of ethyl acetate/petroleum ether 1:1 with addition of 1% glacial acetic acid. The yield of the process was 6.7 g.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US06265588B1
출처 데이터셋uspto-grants-2001_07
ORD IDord-5e2b4484594241b88abc525754992300
출처 메모uspto-grants-2001_07