참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-Methoxyphenol | HCID 9015 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Benzo(b)thiophene, 3-bromo- | HCID 123250 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 3-(4-Methoxyphenoxy)benzo[b]thiophene | HCID 10824975 | — |
반응 단계
A mixture of 4.00 g (19.7 mmol) of 3-bromobenzo[b]thiophene, 4.96 g (40 mmol) of 4-methoxyphenol, 5.52 g (40 mmol) of K2CO3, and 0.20 g (1.0 mmol) of CuI was heated to 140° C. and sonicated at this temperature for 2 h. The reaction was allowed to cool, taken up in CH2Cl2, and the mixture was washed several times with 0.5 N NaOH. The organic layer was dried over Na2SO4 and concentrated in vacuo to an oil that was subjected to chromatography (SiO2; gradient of 0-5% EtOAc in hexanes). The fractions containing the desired product were combined, evaporated in vacuo, and the residue was recrystallized from hexanes to afford 500 mg (1.95 mmol; 10%) of the title compound as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06265575B1 |
|---|
| 출처 데이터셋 | uspto-grants-2001_07 |
|---|
| ORD ID | ord-88fa74840acb457dbd2585d04240b8d3 |
|---|
| 출처 메모 | uspto-grants-2001_07 |
|---|
