Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyrrolidine → Methyl 5-[(1-Pyrrolidinyl)methyl]pyrazine-2-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyrrolidine | HCID 31268 | — |
| 반응물 | Methyl 5-(bromomethyl)pyrazine-2-carboxylate | HCID 21973569 | — |
| 생성물 | Methyl 5-[(1-Pyrrolidinyl)methyl]pyrazine-2-carboxylate | HCID 21182947 | 85% |
반응 단계
By essentially following the procedure used to prepare Example 137, Part B, the title compound was prepared from methyl 5-(bromomethyl)pyrazine-2-carboxylate (Part A) and pyrrolidine in 85% yield as a pale yellow oil. The mixture was subjected to flash chromatography on silica gel, eluting with a gradient of EtOAc(100-95%)/Et3N(0-5%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06265575B1 |
| 출처 데이터셋 | uspto-grants-2001_07 |
| ORD ID | ord-1dbb9e58ce5643789400c3725d81030e |
| 출처 메모 | uspto-grants-2001_07 |