Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Glyceraldehyde → Ethyl acetate methanol ammonium hydroxide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Glyceraldehyde | HCID 751 | — |
| 반응물 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 반응물 | 2-[4-(2-Aminoethyl)phenyl]-3-[4-[2-(1-pyrrolidinyl)ethoxy]benzyl]benzo[b]thiophene | HCID 22462716 | — |
| 용매 | Dichloromethane methanol | HCID 21226129 | — |
| 생성물 | Ethyl acetate methanol ammonium hydroxide | HCID 21901312 | — |
반응 단계
3-[4-[2-(1-Pyrrolidinyl)ethoxy]benzyl]-2-[4-(2-aminoethyl)phenyl]benzo[b]thiophene (113 mg) was dissolved in dichloromethane:methanol (2:1, 6.0 mL), treated with glyceraldehyde (25 mg) and sodium triacetoxyborohydride (60 mg) sequentially and allowed to stir at ambient temperature for 4 h. The reaction mixture was concentrated, and column chromatography with NH4OH:MeOH:EtOAc (3:7:90) afforded the product (56 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06265575B1 |
| 출처 데이터셋 | uspto-grants-2001_07 |
| ORD ID | ord-4498ad6fe0d94a10b0f9560d9c51f511 |
| 출처 메모 | uspto-grants-2001_07 |