Bromine → 5-Bromo-4-methyl-3-nitropyridin-2(1H)-one

HRID 1387272

반응식

HRID 1387272 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][NH:5][C:4](=[O:8])[C:3]=1[N+:9]([O-:11])=[O:10].C([O-])(=O)C.[Na+].[Br:17]Br>C(O)(=O)C.C(OCC)(=O)C>[Br:17][C:7]1[C:2]([CH3:1])=[C:3]([N+:9]([O-:11])=[O:10])[C:4](=[O:8])[NH:5][CH:6]=1

참가 물질

6

반응물 3

HCID 24408BromineHCID 3453702-Hydroxy-4-methyl-3-nitropyridineHCID 517045Sodium Acetate

생성물 1

HCID 217065175-Bromo-4-methyl-3-nitropyridin-2(1H)-one수율 90%

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 8857Ethyl Acetate용매

실험 절차

To a stirred solution of 4-methyl-3-nitro-2-pyridone (0.45 g, 2.9 mmol) in glacial acetic acid (3 mL) was added sodium acetate (0.24 g) followed by bromine (0.15 mL) dropwise. After 5.5 hours, the mixture was diluted with ethyl acetate, washed with water, dried, filtered and concentrated to give 5-bromo-4-methyl-3-nitro-2-pyridone (0.62 g, 2.6 mmol, 90%).

후처리

  1. washwashed with water
  2. customdried
  3. filtrationfiltered
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-ff99ebcc0a0c492eb6637ad3ceb0939a
출처 데이터셋
uspto-grants-2001_07
특허 번호
US06268365B1

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