Dimethylformamide → 3-Amino-4-methoxy-N-(3,4-dichlorophenyl)-benzamide

HRID 1387498

반응식

C(Cl)(=O)C(Cl)=O.[N+:7]([C:10]1[CH:11]=[C:12]([CH:16]=[CH:17][C:18]=1[O:19][CH3:20])[C:13]([OH:15])=O)([O-])=O.CN(C)C=O.[Cl:26][C:27]1[CH:28]=[C:29]([CH:31]=[CH:32][C:33]=1[Cl:34])[NH2:30]>>[NH2:7][C:10]1[CH:11]=[C:12]([CH:16]=[CH:17][C:18]=1[O:19][CH3:20])[C:13]([NH:30][C:29]1[CH:31]=[CH:32][C:33]([Cl:34])=[C:27]([Cl:26])[CH:28]=1)=[O:15]

참가 물질

반응물 4

HCID 6228Dimethylformamide

HCID 72573,4-Dichloroaniline

HCID 65578Oxalyl chloride

HCID 666404-Methoxy-3-nitrobenzoic acid

생성물 1

HCID 99486273-Amino-4-methoxy-N-(3,4-dichlorophenyl)-benzamide수율 68.5%

실험 절차

Prepared according to the procedure described for Example 1 using oxalyl chloride (5.0 mL, 57.31 mmol), 3-nitro-4-methoxybenzoic acid (5.04 g, 25.56 mmol), dimethylformamide (0.5 mL, 6.46 mmol), and 3,4-dichloroaniline (8.3 g, 51 mmol) to afford the product (5.45 g); m.p. 179-182° C.

후처리

customPrepared

출처 및 근거

ORD 기록: ord-a6f7eba676e9442fa6b1ee6f5c9e220a
출처 데이터셋: uspto-grants-2001_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06268387B1

연결된 노트

불러오는 중…