3-Amino-4-methoxybenzanilide → 3-[3-(3,4-Dimethoxyphenyl)-thioureido]-4-methoxy-N-phenyl-benzamide

참여 물질

역할	이름	HCID	투입량
반응물	3-Amino-4-methoxybenzanilide	HCID 8426	—
반응물	4-Isothiocyanato-1,2-dimethoxybenzene	HCID 141856	—
용매	Ethyl Acetate	HCID 8857	—
생성물	3-[3-(3,4-Dimethoxyphenyl)-thioureido]-4-methoxy-N-phenyl-benzamide	HCID 54494429	31.5%

반응 조건

온도	50 °C

반응 단계

A mixture of 3-amino-4-methoxy-N-phenyl-benzamide (0.972 g, 4.0 mmol), 3,4-dimethoxyphenyl isothiocyanate (0.787 g, 4.0 mmol), and ethyl acetate (25 mL) was heated briefly to 50° C. and then allowed to stand overnight at room temperature. The reaction mixture was diluted with ethyl acetate (˜100 mL), heated to 80° C. briefly, then allowed to stand 5 days at room temperature. The precipitate was filtered off to afford the product (0.552 g); m.p. 170-171° C.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US06268387B1
출처 데이터셋	uspto-grants-2001_07
ORD ID	ord-7b59aa02164f4181b473b6ff2d72b4b7
출처 메모	uspto-grants-2001_07