2-Pyridinemethanol,a-(4-nitrophenyl)- → (4-Aminophenyl) (2-pyridyl)methanol

HRID 1387795노트

반응식

HRID 1387795 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[OH:11])=[CH:6][CH:5]=1)([O-])=O>C(O)C>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([CH:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[OH:11])=[CH:6][CH:5]=1

참가 물질

3

반응물 1

HCID 103537882-Pyridinemethanol,a-(4-nitrophenyl)-

생성물 1

HCID 10420323(4-Aminophenyl) (2-pyridyl)methanol수율 95%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

In ethanol (50 ml) was dissolved (4-nitrophenyl)-(2-pyridyl)methanol (2.30 g), and to the mixture was added dried 10% palladium on carbon (0.12 g). Under hydrogen atmosphere, the mixture was stirred at room temperature under atmospheric pressure for 19 hours. The palladium was filtered off, and the filtrate was concentrated. The residue was recrystallized from ethyl acetate-hexane to give (4-aminophenyl) (2-pyridyl)methanol (1.90 g) as pale yellow crystals.

후처리

  1. additionto the mixture was added
  2. dry with materialdried 10% palladium on carbon (0.12 g)
  3. filtrationThe palladium was filtered off
  4. concentrationthe filtrate was concentrated
  5. customThe residue was recrystallized from ethyl acetate-hexane

출처 및 근거

ORD 기록
ord-3a5222d4713948329919980cefa2554d
출처 데이터셋
uspto-grants-2001_07
특허 번호
US06268354B1

반응 노트

불러오는 중…