Pyridine, 2-((4-nitrophenyl)methyl)- → 2-(4-Aminobenzyl)pyridine

HRID 1387912노트

반응식

HRID 1387912 반응식
[N+:1]([C:4]1[CH:16]=[CH:15][C:7]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)=[CH:6][CH:5]=1)([O-])=O>C(O)C.[Pd]>[NH2:1][C:4]1[CH:16]=[CH:15][C:7]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)=[CH:6][CH:5]=1

참가 물질

4

반응물 1

HCID 69292Pyridine, 2-((4-nitrophenyl)methyl)-

생성물 1

HCID 4595252-(4-Aminobenzyl)pyridine수율 84.5%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A mixture of 2-(4-nitrobenzyl)pyridine (J. Chem. Soc., p549, 1929) (1.50 g) and 5% Pd—C (0.15 g) in ethanol (30 ml) was vigorously stirred under hydrogen atmosphere for 8 hours, and the Pd—C was filtered off. The filtrate was concentrated under reduced pressure, and the residue was separated and purified with column chromatography (ethyl acetate/hexane=1:1→2:1) to give 2-(4-aminobenzyl)pyridine (1.09 g) as yellow oil.

후처리

  1. filtrationthe Pd—C was filtered off
  2. concentrationThe filtrate was concentrated under reduced pressure
  3. customthe residue was separated
  4. custompurified with column chromatography (ethyl acetate/hexane=1:1→2:1)

출처 및 근거

ORD 기록
ord-1c7474b3669d496587bc4792e1213229
출처 데이터셋
uspto-grants-2001_07
특허 번호
US06268354B1

반응 노트

불러오는 중…