Formaldehyde → 8-Cyclopropyl-2-methyleneoctanoic acid ethyl ester

HRID 1388140노트

반응식

HRID 1388140 반응식
[CH2:1]([O:3][C:4](=[O:18])[CH:5]([CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH:15]1[CH2:17][CH2:16]1)[C:6](O)=O)[CH3:2].C=O.N1CCCCC1>N1C=CC=CC=1>[CH2:1]([O:3][C:4](=[O:18])[C:5](=[CH2:6])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH:15]1[CH2:16][CH2:17]1)[CH3:2]

참가 물질

5

반응물 3

HCID 712FormaldehydeHCID 8082PiperidineHCID 54024252(6-Cyclopropylhexyl)-malonic acid ethyl ester

생성물 1

HCID 543084848-Cyclopropyl-2-methyleneoctanoic acid ethyl ester

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

2.5 g of 8-cyclopropyl-2-methyleneoctanoic acid ethyl ester, in the form of a yellowish oil, which is purified by chromatography on silica gel (migrating agent: 90:10 petroleum ether/ethyl acetate), are obtained by the procedure described in Example (1b) from 4.53 g of (6-cyclopropylhexyl)-malonic acid ethyl ester 0.64 g of paraformaldehyde, 4 ml of pyridine and 0.2 ml of piperidine.

후처리

  1. custom2.5 g of 8-cyclopropyl-2-methyleneoctanoic acid ethyl ester, in the form of a yellowish oil, which is purified by chromatography on silica gel (migrating agent: 90:10 petroleum ether/ethyl acetate)
  2. customare obtained by the procedure

출처 및 근거

ORD 기록
ord-3f26fd22f769400da0a6802c1f6adace
출처 데이터셋
uspto-grants-1984_02
특허 번호
US04430339

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