Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Methylhomopiperazine → Emedastine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Methylhomopiperazine | HCID 228349 | — |
| 반응물 | Fumaric Acid | HCID 444972 | — |
| 반응물 | 2-chloro-1-(2-ethoxyethyl)-1H-benzimidazole | HCID 10489356 | — |
| 생성물 | Emedastine | HCID 3219 | — |
반응 단계
In the same manner as described in Example 1 using 2-chloro-1-[2-(ethoxy)ethyl]benzimidazole (3.00 g), N-methylhomopiperazine (3.10 g) and fumaric acid (2.63 g), ther are obtained crude crystals, which are recrystallized from ethyl acetate-ethanol to give 1-[2-(ethoxy)ethyl]-2-(4-methyl-1-homopiperazinyl)benzimidazole.difumarate (3.78 g) as colorless needles, m.p. 141°-143° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04430343 |
| 출처 데이터셋 | uspto-grants-1984_02 |
| ORD ID | ord-7062adf2730f4b1ba33bbc33e7b310dd |
| 출처 메모 | uspto-grants-1984_02 |