Dichloromethane → 2-[(4-methylbenzoyl)amino]benzamide

HRID 1388235노트

반응식

HRID 1388235 반응식
[C:1]([NH2:10])(=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[NH2:4].C(Cl)Cl.C(N(CC)CC)C.[C:21]1([CH3:30])[CH:26]=[CH:25][C:24]([C:27](Cl)=[O:28])=[CH:23][CH:22]=1>O>[C:1]([C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH:4][C:27]([C:24]1[CH:25]=[CH:26][C:21]([CH3:30])=[CH:22][CH:23]=1)=[O:28])(=[O:9])[NH2:10]

참가 물질

6

반응물 4

HCID 6344DichloromethaneHCID 6942AnthranilamideHCID 8471TriethylamineHCID 134054-Methylbenzoyl Chloride

생성물 1

HCID 8196472-[(4-methylbenzoyl)amino]benzamide수율 88.2%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a well stirred mixture of anthranilamide (34.05 g; 0.25 mol), methylene chloride (650 ml) and triethylamine (~30 ml) is added p-toluoyl chloride (33 ml; 0.25 mol) dropwise over 25 minutes (a slight exotherm is noted). On completion of the addition, the reaction mixture is stirred for one hour, diluted with water (1000 ml). The mixture is stirred vigorously, filtered, the product washed with water and dried to afford 56.08 g solid, mp 206°-208° C.

후처리

  1. additionOn completion of the addition
  2. stirringthe reaction mixture is stirred for one hour
  3. stirringThe mixture is stirred vigorously
  4. filtrationfiltered
  5. washthe product washed with water
  6. customdried

출처 및 근거

ORD 기록
ord-b9a99c6619c74900803ce805d66cd394
출처 데이터셋
uspto-grants-1984_02
특허 번호
US04431440

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