Barium → 4-(1H-Imidazol-2-yl)-pyridine

HRID 1388380

반응식

HRID 1388380 반응식
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[NH:8][CH2:9][CH2:10][N:11]=2)=[CH:3][CH:2]=1.[Ba]>C(Cl)Cl>[NH:8]1[CH:9]=[CH:10][N:11]=[C:7]1[C:4]1[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=1

참가 물질

4

반응물 2

HCID 5355457BariumHCID 111593874-(4,5-dihydro-1H-imidazol-2-yl)pyridine

생성물 1

HCID 3168174-(1H-Imidazol-2-yl)-pyridine수율 68.1%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

2-(4-pyridyl)-imidazoline (7.0 g, 0.047 M) and barium mangnate (52.5 g) in CH2Cl2 (500 ml) were refluxed with stirring for 24 hrs. The reaction mixture was then filtered through diatomaceous earth, washed with methylene chloride and then ethylacetate. The combined filtrates were concentrated and crystallized from ethylacetate-petroleum ether to give 4-(1H-imidazol-2-yl)pyridine (4.7 g, 67% yield).

후처리

  1. filtrationThe reaction mixture was then filtered through diatomaceous earth
  2. washwashed with methylene chloride
  3. concentrationThe combined filtrates were concentrated
  4. customcrystallized from ethylacetate-petroleum ether

출처 및 근거

ORD 기록
ord-176e8998b12847ccaf529f5389d6b725
출처 데이터셋
uspto-grants-1984_02
특허 번호
US04431653

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