3-(4,5-dihydro-1H-imidazol-2-yl)pyridine → 3-(1H-Imidazol-2-yl)pyridine

HRID 1388386

반응식

HRID 1388386 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[NH:8][CH2:9][CH2:10][N:11]=2)[CH:2]=1.[Mn]([O-])([O-])(=O)=O.[Ba+2]>C(Cl)Cl>[NH:8]1[CH:9]=[CH:10][N:11]=[C:7]1[C:3]1[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=1

참가 물질

4

반응물 2

HCID 2380793-(4,5-dihydro-1H-imidazol-2-yl)pyridineHCID 3084030Barium manganate

생성물 1

HCID 123955003-(1H-Imidazol-2-yl)pyridine수율 65.6%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

2-(3-pyridyl)imidazoline (7.2 g, 0.049 M), and barium manganate (52.5 g) in CH2Cl2 (500 ml) were refluxed for 24 hrs. The reaction mixture was then filtered through diatomaceous earth, washed with ethylacetate (3×200 ml) and methanol (3×100 ml). The combined filtrates were concentrated to yield an oil which was purified on silica gel column, eluted with 20% by volume methanol 80% by volume methylene dichloride, to give 3-(1H-imidazol-2-yl)pyridine (4.66 g, 64.7%).

후처리

  1. filtrationThe reaction mixture was then filtered through diatomaceous earth
  2. washwashed with ethylacetate (3×200 ml) and methanol (3×100 ml)
  3. concentrationThe combined filtrates were concentrated
  4. customto yield an oil which
  5. customwas purified on silica gel column
  6. washeluted with 20% by volume methanol 80% by volume methylene dichloride

출처 및 근거

ORD 기록
ord-f27d69c5337a4b47b0d2a3c9c63d9ba7
출처 데이터셋
uspto-grants-1984_02
특허 번호
US04431653

연결된 노트

불러오는 중…