HCID 13281197, 화합물 → 4-(1h-Imidazol-2-ylmethyl)piperidine

HRID 1388394노트

반응식

HRID 1388394 반응식
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][C:8]2[NH:9][CH:10]=[CH:11][N:12]=2)=[CH:3][CH:2]=1.O(C)[Na]>CO>[NH:9]1[CH:10]=[CH:11][N:12]=[C:8]1[CH2:7][CH:4]1[CH2:5][CH2:6][NH:1][CH2:2][CH2:3]1

참가 물질

4

반응물 2

HCID 13281197HCID 13281197, 화합물HCID 178418582HCID 178418582, 화합물

생성물 1

HCID 132811984-(1h-Imidazol-2-ylmethyl)piperidine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

2-(4-pyridylmethyl)imidazole (4 g, 0.025 M) and platinum oxide (0.4 g) in ethanol (40 ml) and 2 NHCl (50 ml) was hydrogenated at 45 psig for 4 hrs. The catalyst was removed by filtration and the filtrate was stripped to dryness. Crystallization from ethanol gave 4-(1H-imidazol-2-yl-methyl)piperidine as the dihydrochloride salt m.p. 251°-252° C. (5.2 g, 87% yield). The mixture of 2-(4-pyridylmethyl)-imidazole (2.38 g, 10 mM) and NaOCH3 (10 mM) in methanol (20 ml) was stirred for 10 min. and filtered. The filtrate was stripped to dryness and distilled from about 180° to about 200° C./0.3 mmHg to give the free base of 4-(1H-imidazol-2-yl-methyl)piperidine.

후처리

  1. filtrationfiltered
  2. distillationdistilled from about 180° to about 200° C./0.3 mmHg

출처 및 근거

ORD 기록
ord-5be952032a6440e1a03660fd27796aa7
출처 데이터셋
uspto-grants-1984_02
특허 번호
US04431653

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