Acetyl chloride → 2-Methoxyimino-2-(3-acetoxyphenyl)acetic acid

HRID 1388448노트

반응식

HRID 1388448 반응식
[C:1](Cl)(=[O:3])[CH3:2].[CH3:5][O:6][N:7]=[C:8]([C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([OH:18])[CH:13]=1)[C:9]([OH:11])=[O:10]>N1C=CC=CC=1>[CH3:5][O:6][N:7]=[C:8]([C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([O:18][C:1](=[O:3])[CH3:2])[CH:13]=1)[C:9]([OH:11])=[O:10]

참가 물질

4

반응물 2

HCID 6367Acetyl chlorideHCID 543905512-Methoxyimino-2-(3-hydroxyphenyl)acetic acid

생성물 1

HCID 537578682-Methoxyimino-2-(3-acetoxyphenyl)acetic acid수율 100.4%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

Acetyl chloride (4.1 g.) was added with stirring and ice-cooling to a solution of 2-methoxyimino-2-(3-hydroxyphenyl)acetic acid (syn isomer) (5 g.) in pyridine (20 ml.) and the mixture was stirred for 50 minutes at ambient temperature. The reaction mixture was poured into ice-water, adjusted to pH 2.1 and extracted three times with ether. The extract was washed with a saturated sodium chloride aqueous solution and dried over magnesium sulfate. The solvent was thoroughly removed under reduced pressure to give 2-methoxyimino-2-(3-acetoxyphenyl)acetic acid (syn isomer) (6.1 g.).

후처리

  1. stirringthe mixture was stirred for 50 minutes at ambient temperature
  2. extractionextracted three times with ether
  3. washThe extract was washed with a saturated sodium chloride aqueous solution
  4. dry with materialdried over magnesium sulfate
  5. customThe solvent was thoroughly removed under reduced pressure

출처 및 근거

ORD 기록
ord-30b0185f016e4d5db802cddca5e0f632
출처 데이터셋
uspto-grants-1984_02
특허 번호
US04431643

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