N-[2-(4-Benzoyloxyphenyl)-1-methylethyl]-2-(2-benzofuranyl)-2-hydroxyethanamine → N-[2-(4-Hydroxyphenyl)-1-methylethyl]-2-(2-benzofuranyl)-2-hydroxyethanamine

HRID 1388741노트

반응식

HRID 1388741 반응식
C([O:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][CH:17]([NH:19][CH2:20][CH:21]([C:23]2[O:24][C:25]3[CH:31]=[CH:30][CH:29]=[CH:28][C:26]=3[CH:27]=2)[OH:22])[CH3:18])=[CH:12][CH:11]=1)(=O)C1C=CC=CC=1.[H][H]>C(OCC)(=O)C.[Pd]>[OH:9][C:10]1[CH:11]=[CH:12][C:13]([CH2:16][CH:17]([NH:19][CH2:20][CH:21]([C:23]2[O:24][C:25]3[CH:31]=[CH:30][CH:29]=[CH:28][C:26]=3[CH:27]=2)[OH:22])[CH3:18])=[CH:14][CH:15]=1

참가 물질

5

반응물 2

HCID 20470050N-[2-(4-Benzoyloxyphenyl)-1-methylethyl]-2-(2-benzofuranyl)-2-hydroxyethanamineHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 12816512N-[2-(4-Hydroxyphenyl)-1-methylethyl]-2-(2-benzofuranyl)-2-hydroxyethanamine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

N-[2-(4-Benzoyloxyphenyl)-1-methylethyl]-2-(2-benzofuranyl)-2-hydroxyethanamine (2 g) in ethyl acetate (150 ml) was hydrogenated over 5% palladium on charcoal at atmospheric pressure. After uptake of hydrogen had ceased the mixture was filtered and the filtrate evaporated to dryness. Chromatography of the residual oil on Kieselgel 60 (5% methanol in dichloromethane) gave the title compound, m.p. 135°-8°, (EtOAc-ether), as a 94:6 mixture of diastereoisomers.

후처리

  1. filtrationwas filtered
  2. customthe filtrate evaporated to dryness

출처 및 근거

ORD 기록
ord-ca4e6b2e91d245f797dad6261c1c3021
출처 데이터셋
uspto-grants-1984_02
특허 번호
US04432993

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