Thionyl Chloride → 6,7-dihydro-5H-dibenzo[a,c]cycloheptene-4-carbonyl chloride

HRID 1388823노트

반응식

HRID 1388823 반응식
[CH:1]1[C:6]2[C:7]3[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=3[CH2:9][CH2:10][CH2:11][C:5]=2[C:4]([C:16]([OH:18])=O)=[CH:3][CH:2]=1.S(Cl)([Cl:21])=O>>[CH:1]1[C:6]2[C:7]3[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=3[CH2:9][CH2:10][CH2:11][C:5]=2[C:4]([C:16]([Cl:21])=[O:18])=[CH:3][CH:2]=1

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 132813416,7-dihydro-5H-dibenzo[a,c]cycloheptene-4-carboxylic acid

생성물 1

HCID 132813426,7-dihydro-5H-dibenzo[a,c]cycloheptene-4-carbonyl chloride

실험 절차

Under a dry nitrogen atmosphere a stirred solution of 6,7-dihydro-5H-dibenzo[a,c]cycloheptene-4-carboxylic acid (3.4 grams, 0.0142 mole) in thionyl chloride (10 ml) was heated at reflux for 1.5 hours. The excess thionyl chloride was removed by distillation under reduced pressure. Benzene (10 ml) was added and then removed by distillation under reduced pressure to leave 6,7-dihydro-5H-dibenzo[a,c]cycloheptene-4-carbonyl chloride as a residue.

후처리

  1. temperatureat reflux for 1.5 hours
  2. customThe excess thionyl chloride was removed by distillation under reduced pressure
  3. additionBenzene (10 ml) was added
  4. customremoved by distillation under reduced pressure

출처 및 근거

ORD 기록
ord-08acb0c29c804f2398265a17045a6c13
출처 데이터셋
uspto-grants-1984_02
특허 번호
US04433182

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