4,6-Dichloro-5-nitropyrimidine → 4-chloro-6-methoxy-5-nitropyrimidine

HRID 1388892노트

반응식

HRID 1388892 반응식
[N+:1]([C:4]1[C:5]([Cl:11])=[N:6][CH:7]=[N:8][C:9]=1Cl)([O-:3])=[O:2].C[CH2:13][O-:14].[Na+]>>[Cl:11][C:5]1[C:4]([N+:1]([O-:3])=[O:2])=[C:9]([O:14][CH3:13])[N:8]=[CH:7][N:6]=1

참가 물질

3

반응물 2

HCID 203124,6-Dichloro-5-nitropyrimidineHCID 2723922Sodium ethoxide

생성물 1

HCID 2522044-chloro-6-methoxy-5-nitropyrimidine수율 98.3%

실험 절차

100 g 5-nitro 4,6-dichloropyrimidine are heated in 1000 ml sodium ethylate solution (16.8 g sodium) for 10 hours to 50° C. Then the reaction mixture is evaporated under vacuum and the residue is stirred with water and vacuum treated. Subsequently, it is extracted several times with hot petroleum ether (boiling range 40° to 60° C.). After cooling, the crystals are vacuum treated and dried. 46 g 4-chloro-6-methoxy-5-nitropyrimidine are obtained having a melting point of 65° C.

후처리

  1. customThen the reaction mixture is evaporated under vacuum
  2. additiontreated
  3. extractionSubsequently, it is extracted several times with hot petroleum ether (boiling range 40° to 60° C.)
  4. temperatureAfter cooling
  5. additiontreated
  6. customdried

출처 및 근거

ORD 기록
ord-a50f6e391acb4900bcd05d226c670c22
출처 데이터셋
uspto-grants-1984_02
특허 번호
US04434167

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