Benzimidazole → 3-(1H-benzimidazol-1-yl)propanenitrile
반응식
[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.[C:10](#[N:13])[CH:11]=[CH2:12].[OH-].C([N+](C)(C)C)C1C=CC=CC=1>O1CCOCC1>[N:1]1([CH2:12][CH2:11][C:10]#[N:13])[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1참가 물질
5
실험 절차
A mixture of 15.8 grams of 1H-benzimidazole, 8 grams of acrylonitrile and 0.2 ml of benzyltrimethylammonium hydroxide (40% solution in methanol) in 200 ml of dioxane was stirred at room temperature for 24 hours. The solvent was evaporated from the resulting yellow solution under reduced pressure and the residual yellow solid was triturated first with ether and then with water to give 1H-benzimidazole-1-propionitrile melting at about 108°-110° C.
후처리
- customThe solvent was evaporated from the resulting yellow solution under reduced pressure
- customthe residual yellow solid was triturated first with ether
출처 및 근거
- ORD 기록
- ord-5aaa153e88614aac9f923b89f8443bf3
- 출처 데이터셋
- uspto-grants-1984_02
- 특허 번호
- US04434174
반응 노트
불러오는 중…