Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diazomethane → Ethyl 4-methoxy-3-ethoxycarbonyl-1-methylpyrrole-2-acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diazomethane | HCID 9550 | — |
| 반응물 | N-Methyl-N-nitrosourea | HCID 12699 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | Ethyl 3-ethoxycarbonyl-4-hydroxy-1-methylpyrrole-2-acetate | HCID 13345719 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | Ethyl 4-methoxy-3-ethoxycarbonyl-1-methylpyrrole-2-acetate | HCID 20469092 | — |
반응 단계
Ethyl 4-hydroxy-3-ethoxycarbonyl-1-methylpyrrole-2-acetate (20 mmole) is dissolved in 10 μl of diethyl ether containing diazomethane freshly prepared from N-methyl-N-nitrosourea and potassium hydroxide. After the reaction is allowed to stand at room temperature for about 0.5 hour, the ether is evaporated under reduced pressure at mild temperature and the residue, i.e., crude ethyl-4-methoxy-3-ethoxycarbonyl-1-methylpyrrole-2-acetate, is used in the next step without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04434175 |
| 출처 데이터셋 | uspto-grants-1984_02 |
| ORD ID | ord-195bafe7bb434b3881f51fa3bf30cad8 |
| 출처 메모 | uspto-grants-1984_02 |