Ethyl-2-(4-toluyl)-3-dimethylaminopropenoate → Ethyl 5-(p-tolyl)isoxazole-4-carboxylate

HRID 1389008노트

반응식

HRID 1389008 반응식
[CH2:1](OC(=O)C(C1C=CC(C)=CC=1)=CN(C)C)C.[CH2:18]([O:20][C:21](=[O:35])[C:22]([C:27](=[O:34])[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)=[CH:23][N:24](C)C)[CH3:19]>>[CH2:18]([O:20][C:21]([C:22]1[CH:23]=[N:24][O:34][C:27]=1[C:28]1[CH:33]=[CH:32][C:31]([CH3:1])=[CH:30][CH:29]=1)=[O:35])[CH3:19]

참가 물질

3

반응물 2

HCID 54008809Ethyl-2-(4-toluyl)-3-dimethylaminopropenoateHCID 54499154Ethyl-2-benzoyl-3-dimethylaminopropenoate

생성물 1

HCID 22220999Ethyl 5-(p-tolyl)isoxazole-4-carboxylate수율 59%

실험 절차

The procedure of Example 15 was employed utilizing ethyl-2-(4-toluyl)-3-dimethylaminopropenoate in lieu of ethyl-2-benzoyl-3-dimethylaminopropenoate to yield ethyl-5-(4'-methylphenyl)-4-isoxazolecarboxylate (2.03 g.; 59% yield) having a melting point of 42°-44° C. and the following analysis:

출처 및 근거

ORD 기록
ord-4ec352fa59dd41738e872006d4cc8cd2
출처 데이터셋
uspto-grants-1981_01
특허 번호
US04243406

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