HCID 54255784, 화합물 → Ethyl 5-(3-chlorophenyl)isoxazole-4-carboxylate

반응식

[CH2:1]([O:3][C:4](=[O:19])[C:5]([C:10](=[O:18])[C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[CH:12]=1)=[CH:6][N:7](C)C)[CH3:2].C(OC(=O)C(C(=O)C1C=CC=CC=1)=CN(C)C)C>>[CH2:1]([O:3][C:4]([C:5]1[CH:6]=[N:7][O:18][C:10]=1[C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[CH:12]=1)=[O:19])[CH3:2]

참가 물질

반응물 2

HCID 54255784HCID 54255784, 화합물

HCID 54499154Ethyl-2-benzoyl-3-dimethylaminopropenoate

생성물 1

HCID 22221485Ethyl 5-(3-chlorophenyl)isoxazole-4-carboxylate수율 51%

실험 절차

The procedure of Example 15 was employed utilizing ethyl-2-(3'-chlorobenzoyl)-3-dimethylaminopropenoate in lieu of ethyl-2-benzoyl-3-dimethylaminopropenoate to yield ethyl-5-(3'-chlorophenyl)-4-isoxazolecarboxylate (3.2 g.; 51% yield) having a melting point of 75°-77° C. and the following analysis:

출처 및 근거

ORD 기록: ord-2f23c084072246279a3b9f9994bdf5be
출처 데이터셋: uspto-grants-1981_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04243406

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