Potassium Hydroxide → 1-(2-(4-Fluorophenyl)ethyl)piperazine

HRID 1389279

반응식

HRID 1389279 반응식
C(OC([N:6]1[CH2:11][CH2:10][N:9]([CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)[CH2:8][CH2:7]1)=O)C.[OH-].[K+]>C(O)C>[F:20][C:17]1[CH:18]=[CH:19][C:14]([CH2:13][CH2:12][N:9]2[CH2:8][CH2:7][NH:6][CH2:11][CH2:10]2)=[CH:15][CH:16]=1

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 12679858Ethyl 4-[2-(4-fluorophenyl)ethyl]piperazine-1-carboxylate

생성물 1

HCID 112545221-(2-(4-Fluorophenyl)ethyl)piperazine수율 60%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

As in the foregoing Example, 48.6 g of the carbamate is hydrolyzed with 50 g potassium hydroxide in 50 ml ethanol at 120° C. Processing gives 21.5 g (60%) 1-[2-(4-fluorophenyl)ethyl]piperazine with a b.p. of 142° C./3 Torr. It may be transformed into a dimaleate crystallizing from 95% ethanol as a hemihydrate and melting at 164.5°-166.5° C.

출처 및 근거

ORD 기록
ord-e9f1f1b9277a40c581503e7107f1f535
출처 데이터셋
uspto-grants-1981_01
특허 번호
US04243805

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