2-Bromoisovaleric acid → N-(2-fluoro-4-chlorophenyl)valine

반응식

[F:1][C:2]1[CH:8]=[C:7]([Cl:9])[CH:6]=[CH:5][C:3]=1[NH2:4].Br[CH:11]([CH:15]([CH3:17])[CH3:16])[C:12]([OH:14])=[O:13]>>[F:1][C:2]1[CH:8]=[C:7]([Cl:9])[CH:6]=[CH:5][C:3]=1[NH:4][C@H:11]([C:12]([OH:14])=[O:13])[CH:15]([CH3:17])[CH3:16]

참가 물질

반응물 2

HCID 112682-Bromoisovaleric acid

HCID 938984-Chloro-2-fluoroaniline

생성물 1

HCID 54022058N-(2-fluoro-4-chlorophenyl)valine

실험 절차

Following the procedure of Example 17, N-(2-fluoro-4-chlorophenyl)valine (0.79 g) is reacted with α-ethynyl-m-phenoxybenzyl bromide (0.39 g) to yield the α-ethynyl-m-phenoxybenzyl ester of N-(2-fluoro-4-chlorophenyl)valine, MS m/e 451 (M+). N-(2-fluoro-4-chlorophenyl)valine is prepared from 2-fluoro-4-chloroaniline and α-bromoisovaleric acid using the procedure of Example 17.

출처 및 근거

ORD 기록: ord-9d1af699e82d41df954b1ed8d0a82ffd
출처 데이터셋: uspto-grants-1981_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04243819

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