Water → 2-[2-(2-Methoxyethoxy)-5-aminobenzenesulfonamido]-4-hexadecyloxy-5-methylphenol

HRID 1389528노트

반응식

HRID 1389528 반응식
[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[CH:8][C:7]=1[S:15]([NH:18][C:19]1[CH:24]=[C:23]([O:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH3:41])[C:22]([CH3:42])=[CH:21][C:20]=1[OH:43])(=[O:17])=[O:16].[Cl-].[NH4+].O>[Fe].C(O)(C)C>[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([NH2:12])=[CH:8][C:7]=1[S:15]([NH:18][C:19]1[CH:24]=[C:23]([O:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH3:41])[C:22]([CH3:42])=[CH:21][C:20]=1[OH:43])(=[O:16])=[O:17]

참가 물질

6

반응물 3

HCID 962WaterHCID 25517Ammonium ChlorideHCID 127288472-[2'(2-Methoxyethoxy)-5'-nitrobenzenesulfonamido]-4-hexadecyloxy-5-methylphenol

생성물 1

HCID 205128082-[2-(2-Methoxyethoxy)-5-aminobenzenesulfonamido]-4-hexadecyloxy-5-methylphenol

시약·촉매·용매 2

HCID 23925Iron촉매HCID 3776Isopropanol용매

실험 절차

32 g of 2-[2'-(2-methoxyethoxy)-5'-nitrobenzenesulfonamido]-4-hexadecyloxy-5-methylphenol prepared as described in Step (b) above, 24 g of iron powder, 12 g of Fe3O4, 0.6 g of ammonium chloride and 25 ml of water were added to 300 ml of isopropyl alcohol and the mixture was refluxed on a steam bath with stirring for 1 hour. After completion of the reaction, the mixture was filtered while hot and the filtrate was cooled with ice. The crystals thus precipitated were recovered by filtration, washed with 50 ml of isopropyl alcohol and air-dried. Yield: 23 g. Melting Point: 142° to 144° C.

후처리

  1. temperaturethe mixture was refluxed on a steam bath
  2. customAfter completion of the reaction
  3. filtrationthe mixture was filtered while hot and the filtrate
  4. temperaturewas cooled with ice
  5. customThe crystals thus precipitated
  6. filtrationwere recovered by filtration
  7. washwashed with 50 ml of isopropyl alcohol
  8. customair-dried

출처 및 근거

ORD 기록
ord-a3f5a89137844f35ad97d2d6ec3512b4
출처 데이터셋
uspto-grants-1981_01
특허 번호
US04245028

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