Quinoline → cis-2,5-Dimethyl-3-hexene-2,5-diol

HRID 1389569

반응식

HRID 1389569 반응식
C(=O)([O-])[O-].[Ca+2].N1C2C(=CC=CC=2)C=CC=1.[CH3:16][C:17]([OH:25])([C:19]#[C:20][C:21]([CH3:24])([OH:23])[CH3:22])[CH3:18].[H][H]>CO>[CH3:16][C:17]([OH:25])(/[CH:19]=[CH:20]\[C:21]([CH3:24])([OH:23])[CH3:22])[CH3:18]

참가 물질

6

반응물 4

HCID 7047QuinolineHCID 88832,5-Dimethyl-3-hexyne-2,5-diolHCID 10112Calcium CarbonateHCID 178418361HCID 178418361, 화합물2회

생성물 1

HCID 11126394cis-2,5-Dimethyl-3-hexene-2,5-diol수율 99.4%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

1.6 g of 5% palladized calcium carbonate and 0.6 g of quinoline were added to a solution of 24 g of 2,5-dimethyl-hex-3-yne-2,5-diol [Ray et al, Am. Soc., Vol. 74 (1952), p. 1247] in 200 ml of methanol and the mixture was stirred with hydrogen until hydrogen absorption ceased. The catalyst was removed by filtration and the filtrate was evaporated to dryness under reduced pressure to obtain 24.2 g of cis 2,5-dimethyl-hex-3-ene-2,5-diol melting at 64° C. which was used as is for the next step.

후처리

  1. customThe catalyst was removed by filtration
  2. customthe filtrate was evaporated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-468207694ddc487b9aaf2731a4d3a4d5
출처 데이터셋
uspto-grants-1981_01
특허 번호
US04245112

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