Imidazole → 1-(1,1'-Biphenyl)-4-yl-2-(1H-imidazol-1-yl)ethanone

HRID 1389779노트

반응식

HRID 1389779 반응식
[C:1]1([C:7]2[CH:16]=[CH:15][C:10]([C:11](=[O:14])[CH2:12]Br)=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH:17]1[CH:21]=[CH:20][N:19]=[CH:18]1.O>CN(C)C=O>[N:17]1([CH2:12][C:11]([C:10]2[CH:15]=[CH:16][C:7]([C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)=[CH:8][CH:9]=2)=[O:14])[CH:21]=[CH:20][N:19]=[CH:18]1

참가 물질

5

반응물 3

HCID 795ImidazoleHCID 962WaterHCID 672821-(1,1'-Biphenyl)-4-yl-2-bromoethanone

생성물 1

HCID 517091-(1,1'-Biphenyl)-4-yl-2-(1H-imidazol-1-yl)ethanone수율 65.4%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

39 g (0.14 mol) of 4-phenylphenacyl bromide are introduced in portions into a solution of 48.2 g (0.7 mol) of imidazole in 140 ml of dimethylformamide, whilst cooling. The mixture is allowed to subsequently react for 15 hours and the solution is poured into water. The crystal mass which has separated out is recrystallised from ethanol. 24 g (65% of theory) of 4-biphenylyl imidazol-1-yl-methyl ketone of melting point 198° C. are obtained.

후처리

  1. temperaturewhilst cooling
  2. customto subsequently react for 15 hours
  3. customThe crystal mass which has separated out
  4. customis recrystallised from ethanol

출처 및 근거

ORD 기록
ord-30f59f05e9d541cc8c788b4ef056d9b6
출처 데이터셋
uspto-grants-1981_01
특허 번호
US04246274

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