Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 6-Chloro-2-naphthyl 4-piperidyl ketone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 2-Chloronaphthalene | HCID 7056 | — |
| 반응물 | Piperidine-4-carbonyl chloride hydrochloride | HCID 3016318 | — |
| 반응물 | Aluminum(III) Chloride | HCID 6451240 | — |
| 용매 | Nitrobenzene | HCID 7416 | — |
| 생성물 | 6-Chloro-2-naphthyl 4-piperidyl ketone | HCID 54320026 | — |
반응 단계
To a stirred suspension of 3.15 g (19.4 mmoles) of 2-chloronaphthalene and 4.46 g (24.2 mmoles) of 4-piperidinecarbonyl chloride hydrochloride in 60 ml nitrobenzene is added gradually 9.7 g (73 mmoles) of aluminum chloride. The mixture is heated to 65°-70° C. for 2 hours and cooled. Ice water and concentrated HCl are added to the reaction mixture. The solid precipitate is partitioned between aqueous sodium hydroxide solution and ether and the organic phase washed with brine, dried over Na2SO4 and concentrated in vacuo. The residue is recrystallized from cyclohexane to yield 6-chloro-2-naphthyl 4-piperidyl ketone. M.P. 98°-100°-5°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04246268 |
| 출처 데이터셋 | uspto-grants-1981_01 |
| ORD ID | ord-dbb77250e2ca4d9e96ef11d4b596969e |
| 출처 메모 | uspto-grants-1981_01 |