Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrogen Bromide → Fenbufen EP Impurity D
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrogen Bromide | HCID 260 | — |
| 반응물 | Dihydro-5-(4'-hydroxy-4-biphenylyl)-2(3H)-furanone | HCID 20294315 | — |
| 반응물 | 4-(4'-Methoxy-biphenyl-4-yl)-4-oxo-butyric acid | HCID 23005238 | — |
| 생성물 | Fenbufen EP Impurity D | HCID 13930818 | — |
반응 단계
The compound Dihydro-5-(4'-hydroxy-4-biphenylyl)-2(3H)-furanone may be prepared by treating 4'-methoxy-γ-oxo-4-biphenylbutyric acid with hydrogen bromide in acid to produce 4'-hydroxy-γ-oxo-4-biphenylbutyric acid. This in turn is treated with sodium borohydride as described above and then purified with organic solvents to produce the desired product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04247466 |
| 출처 데이터셋 | uspto-grants-1981_01 |
| ORD ID | ord-c96a0bb6a0a24592a8b775bb9406c92a |
| 출처 메모 | uspto-grants-1981_01 |