Pyridine → 5-Morpholinosulfonamido-1-naphthol

HRID 1390089

반응식

HRID 1390089 반응식
[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[C:7]2[OH:12].N1C=CC=CC=1.[O:19]1[CH2:24][CH2:23][N:22]([S:25](Cl)(=[O:27])=[O:26])[CH2:21][CH2:20]1>C(#N)C>[O:19]1[CH2:24][CH2:23][N:22]([S:25]([NH:1][C:2]2[CH:11]=[CH:10][CH:9]=[C:8]3[C:3]=2[CH:4]=[CH:5][CH:6]=[C:7]3[OH:12])(=[O:27])=[O:26])[CH2:21][CH2:20]1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 657465-Amino-1-naphtholHCID 12798265Morpholine-4-sulfonyl chloride

생성물 1

HCID 202948755-Morpholinosulfonamido-1-naphthol

시약·촉매·용매 1

HCID 6342Acetonitrile용매2회

실험 절차

To a solution of 4.8 g. of 5-amino-1-naphthol in 210 ml. of acetonitrile were added 2.5 ml. of pyridine and a mixture of 75 ml. of acetonitrile and 5.6 g. of morpholinosulfonyl chloride was added dropwise thereto under stirring and ice-cooling. Stirring was continued at room temperature for 2 hours and reaction was conducted at 40° C. for 1 hour. The mixture was concentrated and the residue was added to about 150 ml. of water containing 3 ml. of conc. hydrochloric acid. The precipitate thus separated was recovered by filtration, washed with water and then dried to give 6.7 g. of the desired product with m.p. 220°-223° C. (with dec.).

후처리

  1. temperatureice-cooling
  2. stirringStirring
  3. customreaction
  4. waitwas conducted at 40° C. for 1 hour
  5. concentrationThe mixture was concentrated
  6. additionthe residue was added to about 150 ml
  7. customThe precipitate thus separated
  8. filtrationwas recovered by filtration
  9. washwashed with water
  10. customdried
  11. customto give 6.7 g

출처 및 근거

ORD 기록
ord-041a96044e89404187fade2fbd457a2f
출처 데이터셋
uspto-grants-1981_01
특허 번호
US04247629

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