Formylvaline → HCID 20461200, 화합물

HRID 1390124노트

반응식

[F:1][C:2]1[CH:16]=[CH:15][C:5]([O:6][C:7]2[N:12]=[C:11]([CH2:13]Br)[CH:10]=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.[CH:17]([NH:19][CH:20]([CH:24]([CH3:26])[CH3:25])[C:21]([OH:23])=[O:22])=[O:18]>>[F:1][C:2]1[CH:16]=[CH:15][C:5]([O:6][C:7]2[N:12]=[C:11]([CH2:13][C:20]([NH:19][CH:17]=[O:18])([CH:24]([CH3:26])[CH3:25])[C:21]([OH:23])=[O:22])[CH:10]=[CH:9][CH:8]=2)=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 100123Formylvaline

HCID 20461199HCID 20461199, 화합물

생성물 1

HCID 20461200HCID 20461200, 화합물

실험 절차

Following the procedure of Example 1, [6-(4-fluorophenoxy)-2-pyridyl]methyl bromide can be reacted with 2-(N-formylamino)-3-methyl-butanoic acid to give [6-(4-fluorophenoxy)-2-pyridyl]methyl 2-(N-formylamino)-3-methyl-butanoic acid, which is further reacted with methanol, yielding [6-4-fluorophenoxy)-2-pyridyl]methyl 2-amino-3-methylbutanoate.

출처 및 근거

ORD 기록: ord-b95fe72ed5f946c7b92c283eca361b7f
출처 데이터셋: uspto-grants-1981_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04247701

반응 노트

불러오는 중…