Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Methylmorpholine → Boc-MePhe-Leu-OMe
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Methylmorpholine | HCID 7972 | — |
| 반응물 | Isobutyl chloroformate | HCID 62365 | — |
| 반응물 | Boc-N-Me-Phe-OH | HCID 7010602 | — |
| 반응물 | HCl-LeuOMe | HCID 88276507 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | Boc-MePhe-Leu-OMe | HCID 13918317 | — |
반응 단계
To a solution of 28 g of Boc-MePhe-OH and 11.2 ml of N-methylmorpholine in 400 ml of THF are added 13.2 ml of chloroformic acid isobutyl ester at -25°. After 5 minutes, at -25°, 18 g of HCl-Leu-OMe and 11.2 ml of N-methylmorpholine in 200 ml of DMF are added to the solution. After 2 hours, at -15°, the mixture is diluted with ethylacetate, washed with dilute aqueous KHCO3 solution, hydrochloric acid, water, dried and the solvent removed under vacuum to yield the title compound as a viscous oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04247543 |
| 출처 데이터셋 | uspto-grants-1981_01 |
| ORD ID | ord-eb8cf7f9edb54ce4a6914eb9f723860a |
| 출처 메모 | uspto-grants-1981_01 |