Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Pyrrolidone → N-(m-Trifluoromethylphenyl)-3-methylthio-4-chloromethyl-2pyrrolidone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Pyrrolidone | HCID 12025 | — |
| 반응물 | Flurochloridone | HCID 91677 | — |
| 반응물 | Sodium methanethiolate | HCID 4378561 | — |
| 반응물 | Sodium Methoxide | HCID 10942334 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N-(m-Trifluoromethylphenyl)-3-methylthio-4-chloromethyl-2pyrrolidone | HCID 22748887 | 85% |
반응 단계
In the same manner as descried above for Example 1, sodium methyl mercaptide prepared from 6.5 g of a 25% methanol solution of sodium methoxide in 50 ml of dimethylformamide was added to 9.4 g (0.034 mole) of N-(m-trifluoromethylphenyl)-3-chloro-4-chloromethyl-2-pyrrolidone (prepared according to the procedure described in U.S. Pat. No. 4,069,038). The product weighed 9.3 g, representing 85% yield based on the pyrrolidone, structure confirmed by NMR analysis, with refractive index nD30 =1.5028. This compound is shown in Table I as Compound No. 2.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04138495 |
| 출처 데이터셋 | uspto-grants-1979_02 |
| ORD ID | ord-163e4b15a7334f219965573c1058670e |
| 출처 메모 | uspto-grants-1979_02 |