Sodium Methoxide → HCID 178493753, 화합물

HRID 1390310노트

반응식

HRID 1390310 반응식
COC([C:5]1[C:10]([O:11][CH3:12])=[CH:9][N:8]=[CH:7][N:6]=1)=O.ClC1C([C:20](OCC)=[O:21])=NC=NC=1.[CH3:25][O-:26].[Na+]>CO>[CH3:12][O:11][C:10]1[C:5]([O:26][CH3:25])=[N:6][C:7](=[C:20]=[O:21])[NH:8][CH:9]=1

참가 물질

5

반응물 3

HCID 10942334Sodium MethoxideHCID 21329182Ethyl 5-chloropyrimidine-4-carboxylateHCID 21329223Methyl 5-methoxy-4-pyrimidinecarboxylate

생성물 1

HCID 178493753HCID 178493753, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

4-Methoxycarbonyl-5-methoxypyrimidine can be prepared by heating 5-chloro-4-ethoxycarbonylpyrimidine (23 g) with sodium methoxide (15 g) in methanol (230 cc) for 8 hours. The solvent is evaporated off and the residue is suspended in diethyl ether (1000 cc). The suspension is washed with water (50 cc). The organic phase is dried over sodium sulphate, filtered and concentrated to dryness to give 5-methoxy-4-methoxy-carbonylpyrimidine (6 g) melting at 75° C.

후처리

  1. customThe solvent is evaporated off
  2. washThe suspension is washed with water (50 cc)
  3. dry with materialThe organic phase is dried over sodium sulphate
  4. filtrationfiltered
  5. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-1fc770e71a25494a86f55a7b764debea
출처 데이터셋
uspto-grants-1979_02
특허 번호
US04138487

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