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Cl.[CH:2]([NH:5][CH2:6][C:7]([C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[C:11]([OH:16])[CH:10]=1)=[O:8])([CH3:4])[CH3:3].[CH3:17][C:18]1([CH3:25])[CH2:21][CH:20]([C:22](Cl)=[O:23])[CH2:19]1>>[CH:2]([NH:5][CH2:6][C:7]([C:9]1[CH:14]=[CH:13][C:12]([O:15][C:22]([CH:20]2[CH2:21][C:18]([CH3:25])([CH3:17])[CH2:19]2)=[O:23])=[C:11]([OH:16])[CH:10]=1)=[O:8])([CH3:4])[CH3:3]참가 물질
3
실험 절차
Following the procedure described above in Example 58A but using 3,4-dihydroxyphenyl isopropylaminomethyl ketone hydrochloride instead of 3,4-dihydroxyphenyl tert-butylaminomethyl ketone hydrochloride and 3,3-dimethylcyclobutanecarbonyl chloride instead of isovaleryl chloride, there is obtained 3-hydroxy-4-(3,3-dimethylcyclobutanecarbonyloxy)phenyl isopropylaminomethyl ketone; and by interaction of this base with hydrochloric acid there is obtained the hydrochloride salt. When this hydrochloride is catalytically hydrogenated, using a procedure similar to that described above in Example 2B, there is obtained 3-hydroxy-4-(3,3-dimethylcyclobutanecarbonyloxy)- alpha-(isopropylaminomethyl)benzyl alcohol hydrochloride.
출처 및 근거
- ORD 기록
- ord-0dc959e96a19410d9ba070aa57795118
- 출처 데이터셋
- uspto-grants-1979_02
- 특허 번호
- US04138581
연결된 노트
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