Potassium Carbonate → 2-[(4-Fluorophenyl)methyl]oxirane
반응식
ClC1C=C(C(OO)=[O:9])C=CC=1.[F:12][C:13]1[CH:18]=[CH:17][C:16]([CH2:19][CH:20]=[CH2:21])=[CH:15][CH:14]=1.C(=O)([O-])[O-].[K+].[K+]>ClCCl>[F:12][C:13]1[CH:18]=[CH:17][C:16]([CH2:19][CH:20]2[CH2:21][O:9]2)=[CH:15][CH:14]=1참가 물질
5
실험 절차
To a stirred mixture of 86 parts of 3-chlorobenzeneperoxoic acid and 650 parts of dichloromethane are added dropwise (slowly) 53 parts of 1-fluoro-4-(2-propenyl)benzene. Upon completion, stirring is continued overnight at room temperature. Then there are added dropwise 92 parts of a potassium carbonate solution and the layers are separated. The organic phase is washed with a sodium bisulfite solution, dried, filtered and evaporated, yielding 58.4 parts (98%) of 2-(4-fluorophenylmethyl)oxirane as an oily residue.
후처리
- customthe layers are separated
- washThe organic phase is washed with a sodium bisulfite solution
- customdried
- filtrationfiltered
- customevaporated
출처 및 근거
- ORD 기록
- ord-5a099a51298642a5af0a0d643e19e1a5
- 출처 데이터셋
- uspto-grants-1979_02
- 특허 번호
- US04139540
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