Epichlorohydrin → 2-{[(4-Chloronaphthalen-1-yl)oxy]methyl}oxirane

HRID 1390611노트

반응식

HRID 1390611 반응식
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([OH:12])=[CH:4][CH:3]=1.Cl[CH2:14][CH:15]1[CH2:17][O:16]1.[OH-].[K+]>O>[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([O:12][CH2:14][CH:15]2[CH2:17][O:16]2)=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 7835EpichlorohydrinHCID 117874-Chloro-1-naphtholHCID 14797Potassium Hydroxide

생성물 1

HCID 57435422-{[(4-Chloronaphthalen-1-yl)oxy]methyl}oxirane

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a stirred mixture of 44.5 parts of 4-chloro-1-naphthalenol and 115 parts of 2-(chloromethyl)oxirane are added portionwise 17.1 parts of potassium hydroxide (exothermic reaction). When the exothermic reaction is ceased, the whole is heated to reflux and stirred at reflux temperature for 2 hours. Water is added and the whole is extracted twice with trichloromethane. The combined extracts are washed three times with water, dried and evaporated. The residue is distilled, yielding 45.3 parts of 2-[(4-chloro-1-naphthalenyloxy)-methyl]oxirane; bp. 150°-151° C. at 0.2 mm. pressure.

후처리

  1. customWhen the exothermic reaction
  2. temperaturethe whole is heated
  3. temperatureto reflux
  4. temperatureat reflux temperature for 2 hours
  5. extractionthe whole is extracted twice with trichloromethane
  6. washThe combined extracts are washed three times with water
  7. customdried
  8. customevaporated
  9. distillationThe residue is distilled

출처 및 근거

ORD 기록
ord-8f20ce3e32a84aab9f34bf5d0fc97496
출처 데이터셋
uspto-grants-1979_02
특허 번호
US04139540

반응 노트

불러오는 중…