Cysteamine → HCID 12906353, 화합물

반응식

[C:1]([CH:3]1[CH:12]2[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:18]=3[CH:5]([C:6]3[C:11]2=[CH:10][CH:9]=[CH:8][CH:7]=3)[CH2:4]1)#[N:2].N[CH2:20][CH2:21][SH:22]>>[S:22]1[CH2:21][CH2:20][N:2]=[C:1]1[CH:3]1[CH:12]2[C:11]3[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=3[CH:5]([C:18]3[C:13]2=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH2:4]1

참가 물질

반응물 2

HCID 6058Cysteamine

HCID 2403069,10-Dihydro-9,10-ethanoanthracene-11-carbonitrile

생성물 1

HCID 12906353HCID 12906353, 화합물수율 77.6%

반응 조건

온도: 130 °C

실험 절차

A mixture of 11-cyano-9,10-dihydro-9,10-ethanoanthracene (4.6 g) and 2-aminoethanethiol (2.0 g) is stirred at 130° C. for 4 hours. The reaction mixture is recrystallized from ethanol to give 11-(2-thiazolin-2-yl)-9,10-dihydro-9,10-ethanoanthracene (4.5 g) as crystals melting at 160 to 161° C. IR (KBr), 1619 cm-1 (S--C=N).

후처리

customThe reaction mixture is recrystallized from ethanol

출처 및 근거

ORD 기록: ord-c57b8edb294c4b78b51e785958e75cac
출처 데이터셋: uspto-grants-1979_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04139711

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